Diphenylene iodonium

Basic Information

CAS ID: 244-54-2
Molecular Formula: C12H8I+
Molecular Weight: 279.1 g/mol
Monoisotopic Mass: 278.9665 g/mol
Class: Small Molecule
Natural Product: No
Other Names: Dibenziodolium Chloride | Diphenyleneiodonium
Analysis: Drug repositioning mechanism analysis

I+

Compound Structure and Identifier

InChI: InChI=1S/C12H8I/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11/h1-8H/q+1 See All
InChI Key: QFXKXRXFBRLLPQ-UHFFFAOYSA-N
Smiles: [I+]1c2ccccc2c3ccccc13 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0960 NADPH oxidase-2 inhibitor
T1025 NAD(P)H oxidase inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 24981855 Target ID T0960
Uniprot ID NADPH oxidase-2 Name NADPH oxidase-2
Model vitro Fibrosis Disease Skin fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 21537828 Target ID T1025
Uniprot ID NAD(P)H oxidase Name NAD(P)H oxidase
Model vitro Fibrosis Disease Peritoneal fibrosis
Process I
Process II EMT,myofibroblasts differentiation
Process III
Mechanism Targeting Pai-i and α-Sma

Reference Record 3

PubMed ID 17962358 Target ID T1025
Uniprot ID NAD(P)H oxidase Name NAD(P)H oxidase
Model vitro,mice Fibrosis Disease Pancreatic fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism

Related Link

PubChem: 3101
ChEMBL: CHEMBL365739