Fasudil hydrochloride hydrate

Basic Information

CAS ID: 186694-02-0
Molecular Formula: C28H38Cl2N6O5S2
Molecular Weight: 673.7 g/mol
Monoisotopic Mass: 672.172 g/mol
Class: Small Molecule
Natural Product: No
Other Names:
Analysis: Drug repositioning mechanism analysis

NH N S O O N NH N S O O N H2O HCl HCl

Compound Structure and Identifier

InChI: InChI=1S/2C14H17N3O2S.2ClH.H2O/c2*18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;;/h2*1,3-5,7,11,15H,2,6,8-10H2;2*1H;1H2 See All
InChI Key: AACOJGPCMIDLEY-UHFFFAOYSA-N
Smiles: C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.O.Cl.Cl See All
Molfile: Download

Related Target

Target ID Name Interaction
T0340 Rho-associated protein kinase 1 inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 24438608 Target ID T0340
Uniprot ID Rho-associated protein kinase 1 Name Rho-associated protein kinase 1
Model rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGFβ1/CTGF pathway

Reference Record 2

PubMed ID 21743486 Target ID T0340
Uniprot ID Rho-associated protein kinase 1 Name Rho-associated protein kinase 1
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting JNK and TGFβ/Smad

Reference Record 3

PubMed ID 21457293 Target ID T0340
Uniprot ID Rho-associated protein kinase 1 Name Rho-associated protein kinase 1
Model vitro Fibrosis Disease Cardiac fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism Targeting RhoA ROCK pathway

Related Link

PubChem: 23724856
ChEMBL: