Rho-associated protein kinase 1

Basic Information

Uniprot ID: Q13464
Secondary ID: B0YJ91, Q2KHM4, Q59GZ4
Symbol: ROCK1
Other Name: Renal carcinoma antigen NY-REN-35,Rho-associated, coiled-coil-containing protein kinase 1,Rho-associated, coiled-coil-containing protein kinase I,ROCK-I,p160 ROCK-1,p160ROCK
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Kinase,Serine/threonine-protein kinase,Transferase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0125 Fasudil inhibitor
D0276 Fasudil hydrochloride hydrate inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 27576917 Compound ID D0125
CAS 103745-39-7 Name Fasudil
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 26490279 Compound ID D0125
CAS 103745-39-7 Name Fasudil
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 3

PubMed ID 24438608 Compound ID D0276
CAS 186694-02-0 Name Fasudil hydrochloride hydrate
Model rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGFβ1/CTGF pathway

Reference Record 4

PubMed ID 23615507 Compound ID D0125
CAS 103745-39-7 Name Fasudil
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting HIF-1α

Reference Record 5

PubMed ID 22942703 Compound ID D0125
CAS 103745-39-7 Name Fasudil
Model mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 22166971 Compound ID D0125
CAS 103745-39-7 Name Fasudil
Model rat Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 21743486 Compound ID D0276
CAS 186694-02-0 Name Fasudil hydrochloride hydrate
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting JNK and TGFβ/Smad

Reference Record 8

PubMed ID 21457293 Compound ID D0276
CAS 186694-02-0 Name Fasudil hydrochloride hydrate
Model vitro Fibrosis Disease Cardiac fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism Targeting RhoA ROCK pathway

Reference Record 9

PubMed ID 21143420 Compound ID
CAS Name
Model rat Fibrosis Disease Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 10

PubMed ID 21108050 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model vitro Fibrosis Disease Peritoneal fibrosis
Process I
Process II EMT
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 21074289 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model vitro Fibrosis Disease Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 12

PubMed ID 19966781 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model vitro,mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 13

PubMed ID 19633071 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model vitro,human,mice Fibrosis Disease Cystic fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 14

PubMed ID 18356698 Compound ID D0125
CAS 103745-39-7 Name Fasudil
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 15

PubMed ID 16260635 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 16

PubMed ID 11967018 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism Targeting Rho-ROCK signaling

Reference Record 17

PubMed ID 11961044 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 18

PubMed ID 11961044 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model rat Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 19

PubMed ID 11847192 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model rat Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 20

PubMed ID 11394652 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation
Process III prevenet collagen deposition
Mechanism Targeting Rho-ROCK pathway

Reference Record 21

PubMed ID 11208648 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I attenue inflammation
Process II cells migration
Process III prevenet collagen deposition
Mechanism Targeting Rho/ROCK-mediated pathway