Ki16425

Basic Information

CAS ID: 355025-24-0
Molecular Formula: C23H23ClN2O5S
Molecular Weight: 475 g/mol
Monoisotopic Mass: 474.1016 g/mol
Class: Small Molecule
Natural Product: No
Other Names:
Analysis: Drug repositioning mechanism analysis

O O NH N O S O OH Cl

Compound Structure and Identifier

InChI: InChI=1S/C23H23ClN2O5S/c1-14-21(25-23(29)30-15(2)18-5-3-4-6-19(18)24)22(31-26-14)17-9-7-16(8-10-17)13-32-12-11-20(27)28/h3-10,15H,11-13H2,1-2H3,(H,25,29)(H,27,28) See All
InChI Key: LLIFMNUXGDHTRO-UHFFFAOYSA-N
Smiles: CC(OC(=O)Nc1c(C)noc1c2ccc(CSCCC(=O)O)cc2)c3ccccc3Cl See All
Molfile: Download

Related Target

Target ID Name Interaction
T0140 Lysophosphatidic acid receptor 1 antagonist

Related Fibrosis Property

Reference Record 1

PubMed ID 24251962 Target ID T0140
Uniprot ID Lysophosphatidic acid receptor 1 Name Lysophosphatidic acid receptor 1
Model vitro,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts differentiation,cells migration
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 18066075 Target ID T0140
Uniprot ID Lysophosphatidic acid receptor 1 Name Lysophosphatidic acid receptor 1
Model vitro,mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II fibroblasts migration
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 18003779 Target ID T0140
Uniprot ID Lysophosphatidic acid receptor 1 Name Lysophosphatidic acid receptor 1
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Related Link

PubChem: 10367662
ChEMBL: CHEMBL361501