Lysophosphatidic acid receptor 1

Basic Information

Uniprot ID:	Q92633
Secondary ID:	B4DK36
Symbol:	LPAR1
Other Name:	EDG2,LPA receptor 1,LPA-1,Lysophosphatidic acid receptor Edg-2
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	G-protein coupled receptor,Receptor,Transducer

Target Classification

Category I	Category II	Category III
Extracellular	G protein-coupled receptor	Edg receptor

Related Compound

Target ID	Name	Interaction
D0286	Antalpa1	antagonist
D0287	Ki16425	antagonist
D0373	VPC12249	antagonist
D0385	AM095	antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID	24251962	Compound ID	D0286
CAS	1391907-61-1	Name	Antalpa1
Model	vitro,mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	fibroblasts differentiation,cells migration
Process III	prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID	24251962	Compound ID	D0287
CAS	355025-24-0	Name	Ki16425
Model	vitro,mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	fibroblasts differentiation,cells migration
Process III	prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID	21545790	Compound ID	D0373
CAS	403520-23-0	Name	VPC12249
Model	vitro,mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	fibroblasts proliferation
Process III	prevenet collagen deposition
Mechanism	Targeting CTGF

Reference Record 4

PubMed ID	21305523	Compound ID	D0385
CAS	1345614-59-6	Name	AM095
Model	vitro,mice	Fibrosis Disease	Systemic sclerosis
Process I
Process II	myofibroblasts accumulation
Process III	prevenet collagen deposition
Mechanism	Targeting LPA-LPA1 pathway

Reference Record 5

PubMed ID	18066075	Compound ID	D0287
CAS	355025-24-0	Name	Ki16425
Model	vitro,mice	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I
Process II	fibroblasts migration
Process III	prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID	18066075	Compound ID	D0373
CAS	452342-67-5	Name	VPC12249
Model	vitro,mice	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I
Process II	fibroblasts migration
Process III	prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID	18003779	Compound ID	D0287
CAS	355025-24-0	Name	Ki16425
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism