| CAS ID: | 107724-20-9 |
| Molecular Formula: | C24H30O6 |
| Molecular Weight: | 414.5 g/mol |
| Monoisotopic Mass: | 414.2042 g/mol |
| Class: | Small Molecule |
| Natural Product: | No |
| Other Names: | SC-6611O | INSPRA | SC-66110 | EPLERENONE |
| Analysis: | Drug repositioning mechanism analysis |
| InChI: | InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1 | See All |
| InChI Key: | JUKPWJGBANNWMW-VWBFHTRKSA-N | |
| Smiles: | COC(=O)[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@@]34O[C@@H]3C[C@@]5(C)[C@@H](CC[C@@]56CCC(=O)O6)[C@H]14 | See All |
| Molfile: | Download |
| Target ID | Name | Interaction |
|---|---|---|
| T0536 | Mineralocorticoid receptor | antagonist |
Reference Record 1
Reference Record 2
Reference Record 3
| PubMed ID | 29216985 | Target ID | |
| Uniprot ID | Name | ||
| Model | sheep | Fibrosis Disease | Cardiac fibrosis |
| Process I | |||
| Process II | myofibroblasts proliferation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||
Trial Record 1
| ClinicalTrial ID | NCT00401856 | Disease | Cardiac fibrosis |
| Phase | Phase 4 | Status | Unknown |
| First Received | November 22, 2006 | Last Verified | December 11, 2008 |
| Sponsor | Royal Brompton & Harefield NHS Foundation Trust | ||
Trial Record 2
| ClinicalTrial ID | NCT01971593 | Disease | Cardiac fibrosis |
| Phase | Phase 4 | Status | Terminated |
| First Received | October 29, 2013 | Last Verified | May 4, 2018 |
| Sponsor | Washington University School of Medicine | ||
Trial Record 3
| ClinicalTrial ID | NCT01801228 | Disease | Liver fibrosis |
| Phase | Phase 2 | Status | Withdrawn |
| First Received | February 28, 2013 | Last Verified | January 15, 2016 |
| Sponsor | Emma Nilsson | ||
Trial Record 4
| ClinicalTrial ID | NCT02740179 | Disease | Cardiac fibrosis |
| Phase | Not Applicable | Status | Recruiting |
| First Received | April 15, 2016 | Last Verified | March 13, 2019 |
| Sponsor | Massachusetts General Hospital | ||
| PubChem: | 443872 |
| ChEMBL: | CHEMBL1095097 |