Mineralocorticoid receptor

Basic Information

Uniprot ID: P08235
Secondary ID: B0ZBF5
Symbol: NR3C2
Other Name: MCR,MR,Nuclear receptor subfamily 3 group C member 2
Class: Single Protein
Type: pro-fibrotic
Molecular Function: DNA-binding,Receptor

Target Classification

Category I Category II Category III
Intracellular Nuclear receptor NR1 family

Related Compound

Target ID Name Interaction
D0141 Spironolactone antagonist
D0274 BR-4628 antagonist
D0293 Eplerenone antagonist
D0591 Finerenone antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID 24469458 Compound ID D0274
CAS 921622-82-4 Name BR-4628
Model vitro,human,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 2

PubMed ID 24469458 Compound ID D0141
CAS 52-01-7 Name Spironolactone
Model vitro,human,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 3

PubMed ID 24083804 Compound ID D0293
CAS 107724-20-9 Name Eplerenone
Model human Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 4

PubMed ID 23457185 Compound ID D0141
CAS 52-01-7 Name Spironolactone
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 22205374 Compound ID D0141
CAS 52-01-7 Name Spironolactone
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting mTOR/S6K1 signaling

Reference Record 6

PubMed ID 21734100 Compound ID D0293
CAS 107724-20-9 Name Eplerenone
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II EMT,fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 18423812 Compound ID D0141
CAS 52-01-7 Name Spironolactone
Model human Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 18353870 Compound ID
CAS Name
Model vitro Fibrosis Disease Peritoneal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 9

PubMed ID 29061727 Compound ID D0591
CAS 1050477-31-0 Name Finerenone
Model vitro,human Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism