Ku-0063794

Basic Information

CAS ID: 938440-64-3
Molecular Formula: C25H31N5O4
Molecular Weight: 465.6 g/mol
Monoisotopic Mass: 465.2376 g/mol
Class: Small Molecule
Natural Product: No
Other Names: AZD-2014
Analysis: Drug repositioning mechanism analysis

O OH N N N N O N O

Compound Structure and Identifier

InChI: InChI=1S/C25H31N5O4/c1-16-13-30(14-17(2)34-16)25-27-23-20(24(28-25)29-8-10-33-11-9-29)5-6-21(26-23)18-4-7-22(32-3)19(12-18)15-31/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17+ See All
InChI Key: RFSMUFRPPYDYRD-CALCHBBNSA-N
Smiles: COc1ccc(cc1CO)c2ccc3c(nc(nc3n2)N4C[C@@H](C)O[C@@H](C)C4)N5CCOCC5 See All
Molfile: Download

Related Target

Target ID Name Interaction
T1014 mTOR Complex 1 inhibitor
T1015 mTOR Complex 2 inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 23907484 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Fibrosis
Process I
Process II EMT
Process III
Mechanism

Reference Record 2

PubMed ID 23303455 Target ID T1014
Uniprot ID mTOR Complex 1 Name mTOR Complex 1
Model vitro,human Fibrosis Disease Keloid
Process I attenue inflammation
Process II fibroblasts proliferation,fibroblasts migration,fibroblasts apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 23303455 Target ID T1015
Uniprot ID mTOR Complex 2 Name mTOR Complex 2
Model vitro,human Fibrosis Disease Keloid
Process I attenue inflammation
Process II fibroblasts proliferation,fibroblasts migration,fibroblasts apoptosis
Process III prevenet collagen deposition
Mechanism

Related Link

PubChem: 16736978
ChEMBL: CHEMBL1078983