mTOR Complex 1

Basic Information

Uniprot ID:
Secondary ID:
Symbol:
Other Name:
Class: Protein Famliy
Type: pro-fibrotic
Molecular Function:

Target Classification

Category I Category II Category III
Other

Related Compound

Target ID Name Interaction
D0018 Rapamycin inhibitor
D0025 Torkinib inhibitor
D0089 Palomid 529 inhibitor
D0165 AZD8055 inhibitor
D0299 Ku-0063794 inhibitor
D0318 Ku-0068650 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28078713 Compound ID D0089
CAS 914913-88-5 Name Palomid 529
Model vitro,human Fibrosis Disease Liver fibrosis
Process I
Process II fibroblasts-to-myofibroblasts
Process III prevenet collagen deposition
Mechanism Targeting TGF-β signaling

Reference Record 2

PubMed ID 26755732 Compound ID D0165
CAS 1009298-09-2 Name AZD8055
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 26382847 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 24958889 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 23761672 Compound ID
CAS Name
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 23303455 Compound ID D0299
CAS 938440-64-3 Name Ku-0063794
Model vitro,human Fibrosis Disease Keloid
Process I attenue inflammation
Process II fibroblasts proliferation,fibroblasts migration,fibroblasts apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 23303455 Compound ID D0318
CAS Name Ku-0068650
Model vitro,human Fibrosis Disease Keloid
Process I attenue inflammation
Process II fibroblasts proliferation,fibroblasts migration,fibroblasts apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 22609986 Compound ID D0025
CAS 1092351-67-1 Name Torkinib
Model mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ARAF

Reference Record 9

PubMed ID 22561297 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 22427849 Compound ID
CAS Name
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 11

PubMed ID 22343118 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 12

PubMed ID 20861467 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 13

PubMed ID 20727922 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Fibrosis
Process I
Process II cells proliferation
Process III
Mechanism

Reference Record 14

PubMed ID 17804674 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model rat Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 15

PubMed ID 15047702 Compound ID
CAS Name
Model vitro Fibrosis Disease Fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 16

PubMed ID 28112218 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model vitro Fibrosis Disease Fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism