Pioglitazone

Basic Information

CAS ID:	111025-46-8
Molecular Formula:	C19H20N2O3S
Molecular Weight:	356.5 g/mol
Monoisotopic Mass:	356.1195 g/mol
Class:	Small Molecule
Natural Product:	No
Other Names:	GLIZOFAR \| U-72107A \| PIOGLITAZONE \| GLIDIPION \| PIOGLITAZONE HYDROCHLORIDE \| Actos \| Duetact \| DIABIOM
Analysis:	Drug repositioning mechanism analysis

Compound Structure and Identifier

InChI:	InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)	See All
InChI Key:	HYAFETHFCAUJAY-UHFFFAOYSA-N
Smiles:	CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1	See All
Molfile:	Download

Related Target

Target ID	Name	Interaction
T0526	Peroxisome proliferator-activated receptor gamma	agonist

Related Fibrosis Property

Reference Record 1

PubMed ID	23633075	Target ID
Uniprot ID		Name
Model	vitro,rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III
Mechanism	Targeting miR-711-SP1

Reference Record 2

PubMed ID	21127991	Target ID	T0526
Uniprot ID	Peroxisome proliferator-activated receptor gamma	Name	Peroxisome proliferator-activated receptor gamma
Model	vitro	Fibrosis Disease	Corneal fibrosis
Process I
Process II	cells proliferation,myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting TGFβ

Reference Record 3

PubMed ID	18974632	Target ID	T0526
Uniprot ID	Peroxisome proliferator-activated receptor gamma	Name	Peroxisome proliferator-activated receptor gamma
Model	vitro	Fibrosis Disease	Pulmonary fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID	18622247	Target ID	T0526
Uniprot ID	Peroxisome proliferator-activated receptor gamma	Name	Peroxisome proliferator-activated receptor gamma
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID	18556801	Target ID	T0526
Uniprot ID	Peroxisome proliferator-activated receptor gamma	Name	Peroxisome proliferator-activated receptor gamma
Model	vitro,mice	Fibrosis Disease	Cystic fibrosis
Process I	attenue inflammation
Process II
Process III
Mechanism

Reference Record 6

PubMed ID	18313605	Target ID	T0526
Uniprot ID	Peroxisome proliferator-activated receptor gamma	Name	Peroxisome proliferator-activated receptor gamma
Model	rabbit	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID	24161914	Target ID
Uniprot ID		Name
Model	rat	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	fibroblasts accumulation
Process III	prevenet collagen deposition
Mechanism

Trial Record 1

ClinicalTrial ID	NCT00719381	Disease	Cystic fibrosis
Phase	Phase 1	Status	Completed
First Received	July 21, 2008	Last Verified	June 14, 2012
Sponsor	Paul Beringer

Trial Record 2

ClinicalTrial ID	NCT00322868	Disease	Cystic fibrosis
Phase	Not Applicable	Status	Completed
First Received	May 8, 2006	Last Verified	February 23, 2018
Sponsor	University Hospitals Cleveland Medical Center

Trial Record 3

ClinicalTrial ID	NCT00531882	Disease	Cystic fibrosis
Phase	Not Applicable	Status	Completed
First Received	September 19, 2007	Last Verified	October 5, 2017
Sponsor	University Hospitals Cleveland Medical Center

Trial Record 4

ClinicalTrial ID	NCT00570622	Disease	Liver fibrosis
Phase	Phase 4	Status	Completed
First Received	December 11, 2007	Last Verified	November 25, 2008
Sponsor	Medical University of Vienna

Related Link

PubChem:	4829
ChEMBL:	CHEMBL595