Gefitinib

Basic Information

CAS ID: 184475-35-2
Molecular Formula: C22H24ClFN4O3
Molecular Weight: 446.9 g/mol
Monoisotopic Mass: 446.1521 g/mol
Class: Small Molecule
Natural Product: No
Other Names: ZD1839 | GEFITINIB | IRESSA
Analysis: Drug repositioning mechanism analysis

O N N NH F Cl O N O

Compound Structure and Identifier

InChI: InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) See All
InChI Key: XGALLCVXEZPNRQ-UHFFFAOYSA-N
Smiles: COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN4CCOCC4 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0022 Epidermal growth factor receptor antagonist

Related Fibrosis Property

Reference Record 1

PubMed ID 23086930 Target ID T0022
Uniprot ID Epidermal growth factor receptor Name Epidermal growth factor receptor
Model vitro,mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II fibroblasts proliferation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism Targeting EGFR signaling

Related Link

PubChem: 123631
ChEMBL: CHEMBL939