| CAS ID: | 899805-25-5 |
| Molecular Formula: | C21H23F3N6O2 |
| Molecular Weight: | 448.5 g/mol |
| Monoisotopic Mass: | 448.1835 g/mol |
| Class: | Small Molecule |
| Natural Product: | No |
| Other Names: | TANZISERTIB | CC-930 | JNK-930 |
| Analysis: | Drug repositioning mechanism analysis |
| InChI: | InChI=1S/C21H23F3N6O2/c22-11-7-15(23)18(16(24)8-11)28-21-27-17-9-25-20(26-12-1-3-14(31)4-2-12)29-19(17)30(21)13-5-6-32-10-13/h7-9,12-14,31H,1-6,10H2,(H,27,28)(H,25,26,29)/t12-,13-,14-/m0/s1 | See All |
| InChI Key: | IBGLGMOPHJQDJB-IHRRRGAJSA-N | |
| Smiles: | O[C@@H]1CC[C@H](CC1)Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n([C@H]5CCOC5)c3n2 | See All |
| Molfile: | Download |
Reference Record 1
| PubMed ID | 22258492 | Target ID | T0345 |
| Uniprot ID | Mitogen-activated protein kinase 9 | Name | Mitogen-activated protein kinase 9 |
| Model | vitro,human | Fibrosis Disease | Systemic sclerosis |
| Process I | |||
| Process II | fibroblasts activation,fibroblasts differentiation,myofibroblasts accumulation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||
Reference Record 2
| PubMed ID | 22258492 | Target ID | T0344 |
| Uniprot ID | Mitogen-activated protein kinase 8 | Name | Mitogen-activated protein kinase 8 |
| Model | vitro,human | Fibrosis Disease | Systemic sclerosis |
| Process I | |||
| Process II | fibroblasts activation,fibroblasts differentiation,myofibroblasts accumulation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | |||
Trial Record 1
| ClinicalTrial ID | NCT01203943 | Disease | Idiopathic pulmonary fibrosis |
| Phase | Phase 2 | Status | Terminated |
| First Received | September 17, 2010 | Last Verified | September 16, 2013 |
| Sponsor | Celgene Corporation | ||
| PubChem: | |
| ChEMBL: | CHEMBL1950289 |