Mitogen-activated protein kinase 8

Basic Information

Uniprot ID: P45983
Secondary ID: B5BTZ5
Symbol: MAPK8
Other Name: JNK1,MAP kinase 8,MAPK 8,JNK-46,Stress-activated protein kinase 1c,SAPK1c,Stress-activated protein kinase JNK1,c-Jun N-terminal kinase 1
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Kinase,Serine/threonine-protein kinase,Transferase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0345 Tanzisertib inhibitor
D0404 Pyrazolanthrone inhibitor
D0455 CC-401 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 24037431 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I
Process II cells proliferation,HSCs differentiation,HSCs apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 22258492 Compound ID D0345
CAS 899805-25-5 Name Tanzisertib
Model vitro,human Fibrosis Disease Systemic sclerosis
Process I
Process II fibroblasts activation,fibroblasts differentiation,myofibroblasts accumulation
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 19782079 Compound ID D0404
CAS 129-56-6 Name Pyrazolanthrone
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II HSCs activation,HSCs proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 17202416 Compound ID D0455
CAS 395104-30-0 Name CC-401
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II cells apoptosis,myofibroblasts accumulation
Process III prevenet collagen deposition
Mechanism Targeting JNK signaling