IMD0354

Basic Information

CAS ID: 978-62-1
Molecular Formula: C15H8ClF6NO2
Molecular Weight: 383.7 g/mol
Monoisotopic Mass: 383.0148 g/mol
Class: Small Molecule
Natural Product: No
Other Names: IMD-0354
Analysis: Drug repositioning mechanism analysis

OH Cl O NH F F F F F F

Compound Structure and Identifier

InChI: InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25) See All
InChI Key: CHILCFMQWMQVAL-UHFFFAOYSA-N
Smiles: Oc1ccc(Cl)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F See All
Molfile: Download

Related Target

Target ID Name Interaction
T0390 Inhibitor of nuclear factor kappa-B kinase subunit beta inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 22215946 Target ID T0390
Uniprot ID Inhibitor of nuclear factor kappa-B kinase subunit beta Name Inhibitor of nuclear factor kappa-B kinase subunit beta
Model mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II HSCs activation
Process III prevenet collagen deposition
Mechanism Targeting NF-κB signaling

Related Link

PubChem: 5081913
ChEMBL: CHEMBL536151