Inhibitor of nuclear factor kappa-B kinase subunit beta

Basic Information

Uniprot ID: O14920
Secondary ID: B4DZ30, B4E0U4, O75327
Symbol: IKBKB
Other Name: IKKB,I-kappa-B-kinase beta,IKK-B,IKK-beta,IkBKB,I-kappa-B kinase 2,IKK2,Nuclear factor NF-kappa-B inhibitor kinase beta,NFKBIKB
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Kinase,Serine/threonine-protein kinase,Transferase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0348 IMD0354 inhibitor
D0580 Sulfasalazine inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 23041324 Compound ID
CAS Name
Model mice Fibrosis Disease Pancreatic fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 22215946 Compound ID D0348
CAS 978-62-1 Name IMD0354
Model mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II HSCs activation
Process III prevenet collagen deposition
Mechanism Targeting NF-κB signaling

Reference Record 3

PubMed ID 15633128 Compound ID D0580
CAS 599-79-1 Name Sulfasalazine
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II HSCs apoptosis
Process III
Mechanism