Rosiglitazone

Basic Information

CAS ID: 122320-73-4
Molecular Formula: C18H19N3O3S
Molecular Weight: 357.4 g/mol
Monoisotopic Mass: 357.1147 g/mol
Class: Small Molecule
Natural Product: No
Other Names: Avandamet | Avandaryl | BRL-49653 | Rosiglitazone | BRL-49653C | AVANDIA | ROSIGLITAZONE MALEATE | BRL-49653-C
Analysis: Drug repositioning mechanism analysis

N O S O NH O N

Compound Structure and Identifier

InChI: InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23) See All
InChI Key: YASAKCUCGLMORW-UHFFFAOYSA-N
Smiles: CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c3ccccn3 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0526 Peroxisome proliferator-activated receptor gamma agonist

Related Fibrosis Property

Reference Record 1

PubMed ID 22050182 Target ID T0526
Uniprot ID Peroxisome proliferator-activated receptor gamma Name Peroxisome proliferator-activated receptor gamma
Model vitro Fibrosis Disease Vascular fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism Targeting mTOR-p70S6K and -4EBP1 systems

Reference Record 2

PubMed ID 17505534 Target ID T0526
Uniprot ID Peroxisome proliferator-activated receptor gamma Name Peroxisome proliferator-activated receptor gamma
Model mice Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 15734787 Target ID T0526
Uniprot ID Peroxisome proliferator-activated receptor gamma Name Peroxisome proliferator-activated receptor gamma
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II myofibroblasts differentiation
Process III
Mechanism

Reference Record 4

PubMed ID 28973641 Target ID T0526
Uniprot ID Peroxisome proliferator-activated receptor gamma Name Peroxisome proliferator-activated receptor gamma
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II EMT
Process III
Mechanism

Reference Record 5

PubMed ID 20351560 Target ID T0526
Uniprot ID Peroxisome proliferator-activated receptor gamma Name Peroxisome proliferator-activated receptor gamma
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Trial Record 1

ClinicalTrial ID NCT00492700 Disease Liver fibrosis
Phase Phase 2 Status Completed
First Received June 27, 2007 Last Verified June 27, 2007
Sponsor Association pour la Recherche sur les Maladies Hépatiques Virales

Related Link

PubChem: 77999
ChEMBL: CHEMBL121