Irbesartan

Basic Information

CAS ID: 138402-11-6
Molecular Formula: C25H28N6O
Molecular Weight: 428.5 g/mol
Monoisotopic Mass: 428.2325 g/mol
Class: Small Molecule
Natural Product: No
Other Names: IRBESARTAN | BMS-186295 | IFIRMASTA | APROVEL | AVAPRO | SABERVEL | KARVEA | SR 47436
Analysis: Drug repositioning mechanism analysis

N O N N N NH N

Compound Structure and Identifier

InChI: InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30) See All
InChI Key: YOSHYTLCDANDAN-UHFFFAOYSA-N
Smiles: CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)c4ccccc4c5nn[nH]n5 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0118 Type-1 angiotensin II receptor antagonist

Related Fibrosis Property

Reference Record 1

PubMed ID 21769867 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 16971004 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting NF-κB

Reference Record 3

PubMed ID 15149348 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Trial Record 1

ClinicalTrial ID NCT00265642 Disease Liver fibrosis
Phase Phase 3 Status Completed
First Received December 15, 2005 Last Verified February 7, 2014
Sponsor French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)

Related Link

PubChem: 3749
ChEMBL: CHEMBL1513