U0126

Basic Information

CAS ID: 218601-62-8
Molecular Formula: C18H16N6S2
Molecular Weight: 380.5 g/mol
Monoisotopic Mass: 380.0878 g/mol
Class: Small Molecule
Natural Product: No
Other Names: U-0126
Analysis: Drug repositioning mechanism analysis

NH2 N NH2 S NH2 N S NH2

Compound Structure and Identifier

InChI: InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+ See All
InChI Key: DVEXZJFMOKTQEZ-JYFOCSDGSA-N
Smiles: N\C(=C(\C#N)/C(=C(\N)/Sc1ccccc1N)/C#N)\Sc2ccccc2N See All
Molfile:

Related Target

Target ID Name Interaction
T0383 Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
T0384 Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 18440851 Target ID T0383
Uniprot ID Dual specificity mitogen-activated protein kinase kinase 1 Name Dual specificity mitogen-activated protein kinase kinase 1
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 2

PubMed ID 18440851 Target ID T0384
Uniprot ID Dual specificity mitogen-activated protein kinase kinase 2 Name Dual specificity mitogen-activated protein kinase kinase 2
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 3

PubMed ID 16289155 Target ID T0383
Uniprot ID Dual specificity mitogen-activated protein kinase kinase 1 Name Dual specificity mitogen-activated protein kinase kinase 1
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III
Mechanism

Reference Record 4

PubMed ID 16289155 Target ID T0384
Uniprot ID Dual specificity mitogen-activated protein kinase kinase 2 Name Dual specificity mitogen-activated protein kinase kinase 2
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III
Mechanism

Reference Record 5

PubMed ID 29170419 Target ID T0383
Uniprot ID Dual specificity mitogen-activated protein kinase kinase 1 Name Dual specificity mitogen-activated protein kinase kinase 1
Model vitro,human Fibrosis Disease Fibrosis
Process I
Process II cells proliferation
Process III
Mechanism

Reference Record 6

PubMed ID 29170419 Target ID T0384
Uniprot ID Dual specificity mitogen-activated protein kinase kinase 2 Name Dual specificity mitogen-activated protein kinase kinase 2
Model vitro,human Fibrosis Disease Fibrosis
Process I
Process II cells proliferation
Process III
Mechanism

Related Link

PubChem: 3006531
ChEMBL: CHEMBL34704