Dual specificity mitogen-activated protein kinase kinase 1

Basic Information

Uniprot ID:	Q02750
Secondary ID:
Symbol:	MAP2K1
Other Name:	MEK1,MAP kinase kinase 1,MAPKK 1,MKK1,ERK activator kinase 1,MAPKERK kinase 1,MEK 1
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	Kinase,Serine/threonine-protein kinase,Transferase,Tyrosine-protein kinase

Target Classification

Category I	Category II	Category III
Intracellular	Enzyme	Kinase

Related Compound

Target ID	Name	Interaction
D0035	PD98059	inhibitor
D0271	Selumetinib	inhibitor
D0436	U0126	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	25406076	Compound ID	D0035
CAS	167869-21-8	Name	PD98059
Model	vitro,rat	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 2

PubMed ID	24475138	Compound ID	D0271
CAS	606143-52-6	Name	Selumetinib
Model	mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	cells proliferation
Process III	prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID	18440851	Compound ID	D0436
CAS	218601-62-8	Name	U0126
Model	vitro	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 4

PubMed ID	16871530	Compound ID	D0419
CAS	109511-58-2	Name	UO126
Model	vitro,mice	Fibrosis Disease	Dermal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID	16289155	Compound ID	D0436
CAS	218601-62-8	Name	U0126
Model	vitro	Fibrosis Disease	Keloid
Process I
Process II
Process III
Mechanism

Reference Record 6

PubMed ID	16289155	Compound ID	D0465
CAS	19545-26-7	Name	Wortmannin
Model	vitro	Fibrosis Disease	Keloid
Process I
Process II
Process III
Mechanism

Reference Record 7

PubMed ID	29170419	Compound ID	D0436
CAS	218601-62-8	Name	U0126
Model	vitro,human	Fibrosis Disease	Fibrosis
Process I
Process II	cells proliferation
Process III
Mechanism