AG-490

Basic Information

CAS ID: 133550-30-8
Molecular Formula: C17H14N2O3
Molecular Weight: 294.3 g/mol
Monoisotopic Mass: 294.1004 g/mol
Class: Small Molecule
Natural Product: No
Other Names: AG-490
Analysis: Drug repositioning mechanism analysis

HO N O NH OH

Compound Structure and Identifier

InChI: InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+ See All
InChI Key: TUCIOBMMDDOEMM-RIYZIHGNSA-N
Smiles: Oc1ccc(\C=C(/C#N)\C(=O)NCc2ccccc2)cc1O See All
Molfile: Download

Related Target

Target ID Name Interaction
T0357 Tyrosine-protein kinase JAK2 inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 28158495 Target ID T0357
Uniprot ID Tyrosine-protein kinase JAK2 Name Tyrosine-protein kinase JAK2
Model vitro,mice,dog Fibrosis Disease Cardiac fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism Targeting JAK-STAT signaling

Related Link

PubChem: 5328779
ChEMBL: CHEMBL56543