Tyrosine-protein kinase JAK2

Basic Information

Uniprot ID: O60674
Secondary ID: O14636, O75297
Symbol: JAK2
Other Name: Janus kinase 2,JAK-2
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Chromatin regulator,Kinase,Transferase,Tyrosine-protein kinase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0279 NS-018 inhibitor
D0536 AG-490 inhibitor
D0557 Ruxolitinib inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 26569382 Compound ID D0557
CAS 941678-49-5 Name Ruxolitinib
Model vitro,mice Fibrosis Disease Bone marrow fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 24470592 Compound ID D0557
CAS 941678-49-5 Name Ruxolitinib
Model human,mice Fibrosis Disease Bone marrow fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 24413068 Compound ID D0279
CAS 1239358-86-1 Name NS-018
Model vitro,mice Fibrosis Disease Bone marrow fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 21420414 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Vascular fibrosis
Process I
Process II cells proliferation,cells migration,cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 28158495 Compound ID D0536
CAS 133550-30-8 Name AG-490
Model vitro,mice,dog Fibrosis Disease Cardiac fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism Targeting JAK-STAT signaling