Ruxolitinib

Basic Information

CAS ID: 941678-49-5
Molecular Formula: C17H18N6
Molecular Weight: 306.4 g/mol
Monoisotopic Mass: 306.1593 g/mol
Class: Small Molecule
Natural Product: No
Other Names: JAKAVI | JAKAFI | INCB-018424 | RUXOLITINIB PHOSPHATE | RUXOLITINIB | INCB018424 SALT
Analysis: Drug repositioning mechanism analysis

N N N N N NH

Compound Structure and Identifier

InChI: InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1 See All
InChI Key: HFNKQEVNSGCOJV-OAHLLOKOSA-N
Smiles: N#CC[C@H](C1CCCC1)n2cc(cn2)c3ncnc4[nH]ccc34 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0356 Tyrosine-protein kinase JAK1 inhibitor
T0357 Tyrosine-protein kinase JAK2 inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 26569382 Target ID T0356
Uniprot ID Tyrosine-protein kinase JAK1 Name Tyrosine-protein kinase JAK1
Model vitro,mice Fibrosis Disease Bone marrow fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 26569382 Target ID T0357
Uniprot ID Tyrosine-protein kinase JAK2 Name Tyrosine-protein kinase JAK2
Model vitro,mice Fibrosis Disease Bone marrow fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 26088933 Target ID
Uniprot ID Name
Model human Fibrosis Disease Bone marrow fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 4

PubMed ID 24470592 Target ID T0357
Uniprot ID Tyrosine-protein kinase JAK2 Name Tyrosine-protein kinase JAK2
Model human,mice Fibrosis Disease Bone marrow fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Trial Record 1

ClinicalTrial ID NCT03333187 Disease Bone marrow fibrosis
Phase Phase 2 Status Recruiting
First Received November 6, 2017 Last Verified August 27, 2018
Sponsor Universitätsklinikum Hamburg-Eppendorf

Related Link

PubChem: 25126798
ChEMBL: CHEMBL1789941