| Uniprot ID: | P36896 |
| Secondary ID: | B7Z5L8 |
| Symbol: | ACVR1B |
| Other Name: | ACVRLK4,Activin receptor type IB,ACTR-IB,Activin receptor-like kinase 4,ALK-4,Serinethreonine-protein kinase receptor R2,SKR2 |
| Class: | Single Protein |
| Type: | pro-fibrotic |
| Molecular Function: | Kinase,Receptor,Serine/threonine-protein kinase,Transferase |
| Category I | Category II | Category III |
|---|---|---|
| Extracellular | Growth factor and receptor | TGF-beta superfamily |
Reference Record 1
| PubMed ID | 28214509 | Compound ID | |
| CAS | Name | ||
| Model | vitro,mice | Fibrosis Disease | Cardiac fibrosis |
| Process I | |||
| Process II | fibroblasts migration,fibroblasts proliferation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting Smad2/3/4 pathways | ||
Reference Record 2
| PubMed ID | 27379535 | Compound ID | |
| CAS | Name | ||
| Model | vitro,mice | Fibrosis Disease | Cardiac fibrosis |
| Process I | |||
| Process II | fibroblasts proliferation,myofibroblasts differentiation | ||
| Process III | prevenet collagen deposition | ||
| Mechanism | Targeting Smad2/3 signaling | ||
Reference Record 3