SB431542

Basic Information

CAS ID: 301836-41-9
Molecular Formula: C22H16N4O3
Molecular Weight: 384.4 g/mol
Monoisotopic Mass: 384.1222 g/mol
Class: Small Molecule
Natural Product: No
Other Names: SB-431542-A | SB-431542A | SB-431542
Analysis: Drug repositioning mechanism analysis

NH2 O N N NH O O

Compound Structure and Identifier

InChI: InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) See All
InChI Key: FHYUGAJXYORMHI-UHFFFAOYSA-N
Smiles: NC(=O)c1ccc(cc1)c2nc(c3ccccn3)c([nH]2)c4ccc5OCOc5c4 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0007 TGF-beta receptor type-1 inhibitor
T0010 Activin receptor type-1C inhibitor
T0011 Activin receptor type-1B inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 28632033 Target ID T0007
Uniprot ID TGF-beta receptor type-1 Name TGF-beta receptor type-1
Model vitro Fibrosis Disease Subconjunctival fibrosis
Process I
Process II fibroblasts differentiation,HSCs migration
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 28553231 Target ID T0007
Uniprot ID TGF-beta receptor type-1 Name TGF-beta receptor type-1
Model vitro Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II fibroblasts proliferation, fibroblasts migration,fibroblasts-to-myofibroblasts
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 28181132 Target ID T0007
Uniprot ID TGF-beta receptor type-1 Name TGF-beta receptor type-1
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II cells migration,cells proliferation
Process III
Mechanism Targeting TGFβ-1/Smad signaling

Reference Record 4

PubMed ID 27186977 Target ID T0007
Uniprot ID TGF-beta receptor type-1 Name TGF-beta receptor type-1
Model mice Fibrosis Disease Muscle fibrosis
Process I
Process II myofibroblasts activation
Process III prevenet collagen deposition
Mechanism Targeting FAP

Reference Record 5

PubMed ID 27186977 Target ID T0011
Uniprot ID Activin receptor type-1B Name Activin receptor type-1B
Model mice Fibrosis Disease Muscle fibrosis
Process I
Process II myofibroblasts activation
Process III prevenet collagen deposition
Mechanism Targeting FAP

Reference Record 6

PubMed ID 27186977 Target ID T0010
Uniprot ID Activin receptor type-1C Name Activin receptor type-1C
Model mice Fibrosis Disease Muscle fibrosis
Process I
Process II myofibroblasts activation
Process III prevenet collagen deposition
Mechanism Targeting FAP

Reference Record 7

PubMed ID 26227022 Target ID T0007
Uniprot ID TGF-beta receptor type-1 Name TGF-beta receptor type-1
Model vitro,human Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III
Mechanism Targeting IL-13

Reference Record 8

PubMed ID 24347485 Target ID T0007
Uniprot ID TGF-beta receptor type-1 Name TGF-beta receptor type-1
Model vitro,mice Fibrosis Disease Peritoneal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 22328118 Target ID T0007
Uniprot ID TGF-beta receptor type-1 Name TGF-beta receptor type-1
Model vitro Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting Wnt/β-catenin pathway

Reference Record 10

PubMed ID 22245495 Target ID T0007
Uniprot ID TGF-beta receptor type-1 Name TGF-beta receptor type-1
Model vitro Fibrosis Disease Cardiac fibrosis
Process I
Process II EndMT,myofibroblasts differentiation
Process III
Mechanism

Reference Record 11

PubMed ID 19098325 Target ID T0007
Uniprot ID TGF-beta receptor type-1 Name TGF-beta receptor type-1
Model vitro,rabbit Fibrosis Disease Scar
Process I
Process II myofibroblasts differentiation,cells migration
Process III
Mechanism

Reference Record 12

PubMed ID 28647476 Target ID T0007
Uniprot ID TGF-beta receptor type-1 Name TGF-beta receptor type-1
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,HSCs proliferation
Process III
Mechanism

Related Link

PubChem: 4521392
ChEMBL: CHEMBL440084