Dr AFC

Category I	Category II	Category III
Extracellular	Growth factor and receptor	CTGF family

Target ID	Name	Interaction
D0928	Anti-CTGF scFv	inhibitor
D1162	vaccination with HBcΔCTGF138–159	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	28287886	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID	26129822	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	cells proliferation,cells migration
Process III	prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID	27597128	Compound ID
CAS		Name
Model	mice	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID	27562139	Compound ID	D1162
CAS		Name	vaccination with HBcΔCTGF138–159
Model	vitro,mice	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSC activation
Process III	prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID	27249027	Compound ID
CAS		Name
Model	human	Fibrosis Disease	Scar
Process I
Process II
Process III
Mechanism

Reference Record 6

PubMed ID	27108403	Compound ID
CAS		Name
Model	vitro,rat	Fibrosis Disease	Skin fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 7

PubMed ID	25815693	Compound ID
CAS		Name
Model	vitro,rat	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	fibroblasts proliferation,fibroblasts differentiation,fibroblasts migration
Process III
Mechanism

Reference Record 8

PubMed ID	25384022	Compound ID
CAS		Name
Model	human	Fibrosis Disease	Peritoneal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID	25326099	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Skin fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 10

PubMed ID	24393160	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Skin fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 11

PubMed ID	24282226	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Corneal fibrosis
Process I
Process II	fibroblasts migration
Process III
Mechanism

Reference Record 12

PubMed ID	24239602	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I	attenue inflammation
Process II
Process III
Mechanism

Reference Record 13

PubMed ID	24074434	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Scar
Process I
Process II
Process III
Mechanism

Reference Record 14

PubMed ID	23102621	Compound ID
CAS		Name
Model	rat	Fibrosis Disease	Pulmonary fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 15

PubMed ID	23092863	Compound ID
CAS		Name
Model	vitro,rat	Fibrosis Disease	Liver fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 16

PubMed ID	22969957	Compound ID
CAS		Name
Model	human	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 17

PubMed ID	22329991	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Fibrosis
Process I
Process II	cells proliferation
Process III	prevenet collagen deposition
Mechanism

Reference Record 18

PubMed ID	21978691	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Systemic sclerosis
Process I
Process II
Process III
Mechanism

Reference Record 19

PubMed ID	21747166	Compound ID
CAS		Name
Model	vitro,human,mice	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs activation,cells apoptosis
Process III	prevenet collagen deposition
Mechanism

Reference Record 20

PubMed ID	21265950	Compound ID	D0928
CAS		Name	Anti-CTGF scFv
Model	vitro,mice	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 21

PubMed ID	21215756	Compound ID
CAS		Name
Model	vitro,human,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 22

PubMed ID	20660557	Compound ID
CAS		Name
Model	human	Fibrosis Disease	Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 23

PubMed ID	20430035	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 24

PubMed ID	20368699	Compound ID
CAS		Name
Model	mice	Fibrosis Disease	Pancreatic fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 25

PubMed ID	19822645	Compound ID
CAS		Name
Model	human	Fibrosis Disease	Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 26

PubMed ID	19641518	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Skin fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting TGF-β/Smad/CTGF

Reference Record 27

PubMed ID	19565505	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Systemic sclerosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting Col1a2

Reference Record 28

PubMed ID	19541844	Compound ID
CAS		Name
Model	mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	cells proliferation,myofibroblasts differentiation,myofibroblasts accumulation
Process III	prevenet collagen deposition
Mechanism	Targeting CTGF-ILK-Akt pathway

Reference Record 29

PubMed ID	18639630	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Pancreatic fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 30

PubMed ID	18613219	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs activation,HSCs proliferation
Process III	prevenet collagen deposition
Mechanism

Reference Record 31

PubMed ID	18481257	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Systemic sclerosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 32

PubMed ID	18450591	Compound ID
CAS		Name
Model	vitro,human,rabbit	Fibrosis Disease	Eye fibrosis
Process I
Process II	cells migration
Process III	prevenet collagen deposition
Mechanism

Reference Record 33

PubMed ID	17030714	Compound ID
CAS		Name
Model	human	Fibrosis Disease	Eye fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 34

PubMed ID	16914537	Compound ID
CAS		Name
Model	vitro,rat	Fibrosis Disease	Renal fibrosis
Process I
Process II	EMT
Process III
Mechanism

Reference Record 35

PubMed ID	16889607	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II	EMT
Process III	prevenet collagen deposition
Mechanism

Reference Record 36

PubMed ID	16361307	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Pancreatic fibrosis
Process I
Process II	cells migration
Process III
Mechanism

Reference Record 37

PubMed ID	15980944	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 38

PubMed ID	15870892	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Peritoneal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 39

PubMed ID	15574513	Compound ID
CAS		Name
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II	fibroblasts accumulation
Process III
Mechanism

Reference Record 40

PubMed ID	15566956	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Renal fibrosis
Process I
Process II	EMT,myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism

Reference Record 41

PubMed ID	15256388	Compound ID
CAS		Name
Model	mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	myofibroblasts accumulation
Process III	prevenet collagen deposition
Mechanism

Reference Record 42

PubMed ID	15153554	Compound ID
CAS		Name
Model	rat	Fibrosis Disease	Renal fibrosis
Process I
Process II	myofibroblast differentiation,fibroblasts migration
Process III	prevenet collagen deposition
Mechanism

Reference Record 43

PubMed ID	12947014	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 44

PubMed ID	12819040	Compound ID
CAS		Name
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 45

PubMed ID	12819040	Compound ID
CAS		Name
Model	rat	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 46

PubMed ID	11934704	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 47

PubMed ID	11847192	Compound ID	D0306
CAS	146986-50-7	Name	Y27632
Model	rat	Fibrosis Disease	Vascular fibrosis
Process I	attenue inflammation
Process II	cells proliferation
Process III	prevenet collagen deposition
Mechanism

Reference Record 48

PubMed ID	11934704	Compound ID
CAS		Name
Model	vitro,rat	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 49

PubMed ID	11576939	Compound ID
CAS		Name
Model	vitro	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Uniprot ID:	P29279
Secondary ID:	E1P578
Symbol:	CTGF
Other Name:	CCN2,CCN family member 2,Hypertrophic chondrocyte-specific protein 24,Insulin-like growth factor-binding protein 8,IBP-8,IGF-binding protein 8,IGFBP-8
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	Heparin-binding

Connective tissue growth factor

Basic Information

Target Classification

Related Compound

Fibrosis Related Property