Dr AFC

Target ID	Name	Interaction
T0341	Rho-associated protein kinase 2	inhibitor
T0944	Rho-associated protein kinase	inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID	23550216	Target ID	T0944
Uniprot ID	Rho-associated protein kinase	Name	Rho-associated protein kinase
Model	vitro	Fibrosis Disease	Eye fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 2

PubMed ID	21108050	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	vitro	Fibrosis Disease	Peritoneal fibrosis
Process I
Process II	EMT
Process III	prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID	21074289	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	vitro	Fibrosis Disease	Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 4

PubMed ID	19966781	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	vitro,mice	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID	19633071	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	vitro,human,mice	Fibrosis Disease	Cystic fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 6

PubMed ID	11967018	Target ID	T0944
Uniprot ID	Rho-associated protein kinase	Name	Rho-associated protein kinase
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II	fibroblasts proliferation
Process III	prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID	11961044	Target ID	T0944
Uniprot ID	Rho-associated protein kinase	Name	Rho-associated protein kinase
Model	rat	Fibrosis Disease	Vascular fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID	11961044	Target ID	T0944
Uniprot ID	Rho-associated protein kinase	Name	Rho-associated protein kinase
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID	11847192	Target ID	T0043
Uniprot ID	Connective tissue growth factor	Name	Connective tissue growth factor
Model	rat	Fibrosis Disease	Vascular fibrosis
Process I	attenue inflammation
Process II	cells proliferation
Process III	prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID	21439370	Target ID	T0944
Uniprot ID	Rho-associated protein kinase	Name	Rho-associated protein kinase
Model	vitro,mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	cells proliferation
Process III	prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID	11967018	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II	fibroblasts proliferation
Process III	prevenet collagen deposition
Mechanism	Targeting Rho-ROCK signaling

Reference Record 12

PubMed ID	11967018	Target ID	T0341
Uniprot ID	Rho-associated protein kinase 2	Name	Rho-associated protein kinase 2
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II	fibroblasts proliferation
Process III	prevenet collagen deposition
Mechanism	Targeting Rho-ROCK signaling

Reference Record 13

PubMed ID	11961044	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 14

PubMed ID	11961044	Target ID	T0341
Uniprot ID	Rho-associated protein kinase 2	Name	Rho-associated protein kinase 2
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 15

PubMed ID	11961044	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	rat	Fibrosis Disease	Vascular fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 16

PubMed ID	11961044	Target ID	T0341
Uniprot ID	Rho-associated protein kinase 2	Name	Rho-associated protein kinase 2
Model	rat	Fibrosis Disease	Vascular fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 17

PubMed ID	11847192	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I	attenue inflammation
Process II	fibroblasts proliferation
Process III	prevenet collagen deposition
Mechanism

Reference Record 18

PubMed ID	11847192	Target ID	T0341
Uniprot ID	Rho-associated protein kinase 2	Name	Rho-associated protein kinase 2
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I	attenue inflammation
Process II	fibroblasts proliferation
Process III	prevenet collagen deposition
Mechanism

Reference Record 19

PubMed ID	11394652	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	vitro,rat	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs activation
Process III	prevenet collagen deposition
Mechanism	Targeting Rho-ROCK pathway

Reference Record 20

PubMed ID	11394652	Target ID	T0341
Uniprot ID	Rho-associated protein kinase 2	Name	Rho-associated protein kinase 2
Model	vitro,rat	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs activation
Process III	prevenet collagen deposition
Mechanism	Targeting Rho-ROCK pathway

Reference Record 21

PubMed ID	11208648	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	vitro	Fibrosis Disease	Pulmonary fibrosis
Process I	attenue inflammation
Process II	cells migration
Process III	prevenet collagen deposition
Mechanism	Targeting Rho/ROCK-mediated pathway

Reference Record 22

PubMed ID	11208648	Target ID	T0341
Uniprot ID	Rho-associated protein kinase 2	Name	Rho-associated protein kinase 2
Model	vitro	Fibrosis Disease	Pulmonary fibrosis
Process I	attenue inflammation
Process II	cells migration
Process III	prevenet collagen deposition
Mechanism	Targeting Rho/ROCK-mediated pathway

CAS ID:	146986-50-7
Molecular Formula:	C14H21N3O
Molecular Weight:	247.3 g/mol
Monoisotopic Mass:	247.1685 g/mol
Class:	Small Molecule
Natural Product:	No
Other Names:	Y-27632
Analysis:	Drug repositioning mechanism analysis

InChI:	InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1	See All
InChI Key:	IYOZTVGMEWJPKR-IJLUTSLNSA-N
Smiles:	C[C@@H](N)[C@@H]1CC[C@H](CC1)C(=O)Nc2ccncc2	See All
Molfile:	Download

Y27632

Basic Information

Compound Structure and Identifier

Related Target

Related Fibrosis Property

Related Link

PubChem:
ChEMBL:	CHEMBL559147