Prostaglandin E2 receptor EP2 subtype

Basic Information

Uniprot ID:	P43116
Secondary ID:	D3DSC0, Q52LG8
Symbol:	PTGER2
Other Name:	PGE receptor EP2 subtype,PGE2 receptor EP2 subtype,Prostanoid EP2 receptor
Class:	Single Protein
Type:	anti-fibrotic
Molecular Function:	G-protein coupled receptor,Receptor,Transducer

Target Classification

Category I	Category II	Category III
Extracellular	G protein-coupled receptor	Prostanoid receptor

Related Compound

Target ID	Name	Interaction
D0004	Prostaglandin E2	activator
D0031	Alprostadil	agonist

Fibrosis Related Property

Reference Record 1

PubMed ID	28864467	Compound ID	D0004
CAS	363-24-6	Name	Prostaglandin E2
Model	vitro,human,mice	Fibrosis Disease	Liver fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting Epac-1

Reference Record 2

PubMed ID	28644845	Compound ID	D0031
CAS	745-65-3	Name	Alprostadil
Model	vitro	Fibrosis Disease	Keloid
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting ERK/Ets-1 signaling