Cannabinoid receptor 1

Basic Information

Uniprot ID: P21554
Secondary ID: B2R9T4
Symbol: CNR1
Other Name: CNR,CB-R,CB1,CANN6
Class: Single Protein
Type: pro-fibrotic
Molecular Function: G-protein coupled receptor,Receptor,Transducer

Target Classification

Category I Category II Category III
Extracellular G protein-coupled receptor Cannabinoid receptor

Related Compound

Target ID Name Interaction
D0066 Rimonabant antagonist
D0067 AM6545 antagonist
D0595 Compound 7 antagonist
D0597 MRI-1867 antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID 28422760 Compound ID D0597
CAS Name MRI-1867
Model vitro,human,mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting CB1R and iNOS activity

Reference Record 2

PubMed ID 28422760 Compound ID D0066
CAS 168273-06-1 Name Rimonabant
Model vitro,human,mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting CB1R and iNOS activity

Reference Record 3

PubMed ID 28422760 Compound ID D0067
CAS 1245626-05-4 Name AM6545
Model vitro,human,mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting CB1R and iNOS activity

Reference Record 4

PubMed ID 28085283 Compound ID D0595
CAS Name Compound 7
Model Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 5

PubMed ID 27525312 Compound ID D0597
CAS Name MRI-1867
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 25760323 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Renal fibrosis
Process I
Process II myofibroblasts activation
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 19942623 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism