Cannabinoid receptor 2

Basic Information

Uniprot ID: P34972
Secondary ID: C6ES44
Symbol: CNR2
Other Name: CB2A,CB-2,CB2,hCB2,CX5
Class: Single Protein
Type: anti-fibrotic
Molecular Function: G-protein coupled receptor,Receptor,Transducer

Target Classification

Category I Category II Category III
Extracellular G protein-coupled receptor Cannabinoid receptor

Related Compound

Target ID Name Interaction
D0119 AM1241 agonist
D0241 LY3038404 HCl agonist
D0425 JWH-133 agonist

Fibrosis Related Property

Reference Record 1

PubMed ID 27614871 Compound ID D0119
CAS 444912-48-5 Name AM1241
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting Nrf2-Mediated Inhibition of TGF-β1/Smad3 pathway

Reference Record 2

PubMed ID 25403433 Compound ID D0241
CAS Name LY3038404 HCl
Model rat Fibrosis Disease Pancreatic fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 23813495 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III
Mechanism

Reference Record 4

PubMed ID 19333940 Compound ID D0425
CAS 259869-55-1 Name JWH-133
Model mice Fibrosis Disease Systemic sclerosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 19246487 Compound ID D0425
CAS 259869-55-1 Name JWH-133
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II myofibroblasts differentiation,cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 15765409 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Liver fibrosis
Process I
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism