Substance-P receptor

Basic Information

Uniprot ID:	P25103
Secondary ID:	A8K150
Symbol:	TACR1
Other Name:	NK1R,SPR,NK-1 receptor,NK-1R,Tachykinin receptor 1
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	G-protein coupled receptor,Receptor,Transducer

Target Classification

Category I	Category II	Category III
Extracellular	G protein-coupled receptor	Other peptide receptor

Related Compound

Target ID	Name	Interaction
D0583	L732138	antagonist
D0584	RP67580	antagonist
D0979	Substance P	receptor

Fibrosis Related Property

Reference Record 1

PubMed ID	28647476	Compound ID	D0583
CAS	148451-96-1	Name	L732138
Model	vitro	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs activation,HSCs proliferation,HSC apoptosis
Process III
Mechanism

Reference Record 2

PubMed ID	28647476	Compound ID	D0584
CAS	135911-02-3	Name	RP67580
Model	vitro	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs activation,HSCs proliferation
Process III
Mechanism

Reference Record 3

PubMed ID	20889569	Compound ID	D0979
CAS	33507-63-0	Name	Substance P
Model	vitro,mice	Fibrosis Disease	Intestinal fibrosis
Process I
Process II	fibroblasts migration
Process III	prevenet collagen deposition
Mechanism