Angiotensin-converting enzyme 2

Basic Information

Uniprot ID: Q9BYF1
Secondary ID: C7ECU1
Symbol: ACE2
Other Name: ACE-related carboxypeptidase,Angiotensin-converting enzyme homolog,ACEH,Metalloprotease MPROT15,Processed angiotensin-converting enzyme 2
Class: Single Protein
Type: anti-fibrotic
Molecular Function: Carboxypeptidase,Host cell receptor for virus entry,Hydrolase,Metalloprotease,Protease,Receptor

Target Classification

Category I Category II Category III
Extracellular TIMP/MMP MMP

Related Compound

Target ID Name Interaction
D0123 Diminazene Aceturate activator
D0427 Xnt activator

Fibrosis Related Property

Reference Record 1

PubMed ID 28656296 Compound ID
CAS Name
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ACE2-Ang-MasR axis

Reference Record 2

PubMed ID 27592222 Compound ID D0123
CAS 908-54-3 Name Diminazene Aceturate
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ACE2-Ang-(1-7)-Mas and KCa3.1 channel

Reference Record 3

PubMed ID 25998889 Compound ID
CAS Name
Model mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I attenue inflammation
Process II fibroblasts activation,fibroblasts proliferation,fibroblasts differetiation,cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 25997428 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II HSCs activation
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 24695436 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Muscle fibrosis
Process I attenue inflammation
Process II
Process III
Mechanism

Reference Record 6

PubMed ID 20507236 Compound ID
CAS Name
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 19246717 Compound ID D0427
CAS 86456-22-6 Name Xnt
Model rat Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 16788004 Compound ID
CAS Name
Model rat Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 16049057 Compound ID
CAS Name
Model vitro,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism