Glycogen synthase kinase-3 alpha

Basic Information

Uniprot ID: P49840
Secondary ID: O14959
Symbol: GSK3A
Other Name: GSK-3 alpha,Serinethreonine-protein kinase GSK3A
Class: Single Protein
Type: anti-fibrotic
Molecular Function: Kinase,Serine/threonine-protein kinase,Signal transduction inhibitor,Transferase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0319 SB216763 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 23297769 Compound ID D0319
CAS 280744-09-4 Name SB216763
Model vitro,human Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts proliferation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism Targeting CREB-dependent signaling

Reference Record 2

PubMed ID 19959748 Compound ID D0319
CAS 280744-09-4 Name SB216763
Model mice Fibrosis Disease Pulmonary fibrosis
Process I attenue inflammation
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 16543730 Compound ID
CAS Name
Model vitro Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism