SB216763

Basic Information

CAS ID: 280744-09-4
Molecular Formula: C19H12Cl2N2O2
Molecular Weight: 371.2 g/mol
Monoisotopic Mass: 370.0276 g/mol
Class: Small Molecule
Natural Product: No
Other Names: SB-216763
Analysis: Drug repositioning mechanism analysis

N O NH O Cl Cl

Compound Structure and Identifier

InChI: InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25) See All
InChI Key: JCSGFHVFHSKIJH-UHFFFAOYSA-N
Smiles: Cn1cc(C2=C(C(=O)NC2=O)c3ccc(Cl)cc3Cl)c4ccccc14 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0338 Glycogen synthase kinase-3 alpha inhibitor
T0339 Glycogen synthase kinase-3 beta inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 23297769 Target ID T0338
Uniprot ID Glycogen synthase kinase-3 alpha Name Glycogen synthase kinase-3 alpha
Model vitro,human Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts proliferation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism Targeting CREB-dependent signaling

Reference Record 2

PubMed ID 23297769 Target ID T0339
Uniprot ID Glycogen synthase kinase-3 beta Name Glycogen synthase kinase-3 beta
Model vitro,human Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts proliferation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism Targeting CREB-dependent signaling

Reference Record 3

PubMed ID 19959748 Target ID T0338
Uniprot ID Glycogen synthase kinase-3 alpha Name Glycogen synthase kinase-3 alpha
Model mice Fibrosis Disease Pulmonary fibrosis
Process I attenue inflammation
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Related Link

PubChem: 176158
ChEMBL: CHEMBL102714