Glycogen synthase kinase-3 beta

Basic Information

Uniprot ID: P49841
Secondary ID: D3DN89, Q9BWH3, Q9UL47
Symbol: GSK3B
Other Name: GSK-3 beta,Serinethreonine-protein kinase GSK3B
Class: Single Protein
Type: pro/anti-fibrotic
Molecular Function: Developmental protein,Kinase,Serine/threonine-protein kinase,Signal transduction inhibitor,Transferase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0319 SB216763 inhibitor
D0528 9ING41 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 27628899 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 23297769 Compound ID D0319
CAS 280744-09-4 Name SB216763
Model vitro,human Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts proliferation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism Targeting CREB-dependent signaling

Reference Record 3

PubMed ID 21873331 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Dermal fibrosis
Process I
Process II fibroblasts activation,fibroblasts differentiation
Process III prevenet collagen deposition
Mechanism Targeting Wnt signaling

Reference Record 4

PubMed ID 16543730 Compound ID
CAS Name
Model vitro Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 5

PubMed ID 29073967 Compound ID D0528
CAS 1034895-42-5 Name 9ING41
Model vitro,mice Fibrosis Disease Pleural fibrosis
Process I
Process II cells differentiation,myofibroblasts accumulation
Process III
Mechanism