Mitogen-activated protein kinase 12

Basic Information

Uniprot ID:	P53778
Secondary ID:	Q14260
Symbol:	MAPK12
Other Name:	ERK6,MAP kinase 12,MAPK 12,Extracellular signal-regulated kinase 6,ERK-6,Mitogen-activated protein kinase p38 gamma,MAP kinase p38 gamma,Stress-activated protein kinase 3
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	Kinase,Serine/threonine-protein kinase,Transferase

Target Classification

Category I	Category II	Category III
Intracellular	Enzyme	Kinase

Related Compound

Target ID	Name	Interaction
D0350	FR167653	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	22166971	Compound ID	D0350
CAS	158876-66-5	Name	FR167653
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID	19526623	Compound ID	D0350
CAS	158876-66-5	Name	FR167653
Model	pig	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID	18515792	Compound ID	D0350
CAS	158876-66-5	Name	FR167653
Model	mice	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II	myofibroblasts accumulation
Process III	prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID	16816533	Compound ID	D0350
CAS	158876-66-5	Name	FR167653
Model	rat	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism