FR167653

Basic Information

CAS ID: 158876-66-5
Molecular Formula: C24H20FN5O6S
Molecular Weight: 525.5 g/mol
Monoisotopic Mass: 525.112 g/mol
Class: Small Molecule
Natural Product: No
Other Names:
Analysis: Drug repositioning mechanism analysis

N NH N N F N O O HO S O O OH

Compound Structure and Identifier

InChI: InChI=1S/C24H18FN5O2.H2O4S/c25-19-8-6-17(7-9-19)21-20(16-10-12-26-13-11-16)23-28-30(15-14-29(23)27-21)24(32)22(31)18-4-2-1-3-5-18;1-5(2,3)4/h1-13,28H,14-15H2;(H2,1,2,3,4) See All
InChI Key: KCPHXRBKBLJJJJ-UHFFFAOYSA-N
Smiles: C1CN(NC2=C(C(=NN21)C3=CC=C(C=C3)F)C4=CC=NC=C4)C(=O)C(=O)C5=CC=CC=C5.OS(=O)(=O)O See All
Molfile: Download

Related Target

Target ID Name Interaction
T0346 Mitogen-activated protein kinase 11 inhibitor
T0347 Mitogen-activated protein kinase 12 inhibitor
T0348 Mitogen-activated protein kinase 13 inhibitor
T0349 Mitogen-activated protein kinase 14 inhibitor
T0985 p38 mitogen-activated protein kinases inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 22166971 Target ID T0346
Uniprot ID Mitogen-activated protein kinase 11 Name Mitogen-activated protein kinase 11
Model rat Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 22166971 Target ID T0347
Uniprot ID Mitogen-activated protein kinase 12 Name Mitogen-activated protein kinase 12
Model rat Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 22166971 Target ID T0348
Uniprot ID Mitogen-activated protein kinase 13 Name Mitogen-activated protein kinase 13
Model rat Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 22166971 Target ID T0349
Uniprot ID Mitogen-activated protein kinase 14 Name Mitogen-activated protein kinase 14
Model rat Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 19526623 Target ID T0346
Uniprot ID Mitogen-activated protein kinase 11 Name Mitogen-activated protein kinase 11
Model pig Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 19526623 Target ID T0347
Uniprot ID Mitogen-activated protein kinase 12 Name Mitogen-activated protein kinase 12
Model pig Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 19526623 Target ID T0348
Uniprot ID Mitogen-activated protein kinase 13 Name Mitogen-activated protein kinase 13
Model pig Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 19526623 Target ID T0349
Uniprot ID Mitogen-activated protein kinase 14 Name Mitogen-activated protein kinase 14
Model pig Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 18515792 Target ID T0346
Uniprot ID Mitogen-activated protein kinase 11 Name Mitogen-activated protein kinase 11
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II myofibroblasts accumulation
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 18515792 Target ID T0347
Uniprot ID Mitogen-activated protein kinase 12 Name Mitogen-activated protein kinase 12
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II myofibroblasts accumulation
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 18515792 Target ID T0348
Uniprot ID Mitogen-activated protein kinase 13 Name Mitogen-activated protein kinase 13
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II myofibroblasts accumulation
Process III prevenet collagen deposition
Mechanism

Reference Record 12

PubMed ID 18515792 Target ID T0349
Uniprot ID Mitogen-activated protein kinase 14 Name Mitogen-activated protein kinase 14
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II myofibroblasts accumulation
Process III prevenet collagen deposition
Mechanism

Reference Record 13

PubMed ID 16816533 Target ID T0346
Uniprot ID Mitogen-activated protein kinase 11 Name Mitogen-activated protein kinase 11
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 14

PubMed ID 16816533 Target ID T0347
Uniprot ID Mitogen-activated protein kinase 12 Name Mitogen-activated protein kinase 12
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 15

PubMed ID 16816533 Target ID T0348
Uniprot ID Mitogen-activated protein kinase 13 Name Mitogen-activated protein kinase 13
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 16

PubMed ID 16816533 Target ID T0349
Uniprot ID Mitogen-activated protein kinase 14 Name Mitogen-activated protein kinase 14
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 17

PubMed ID 11728947 Target ID
Uniprot ID Name
Model vitro,rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting p38 MAPK

Reference Record 18

PubMed ID 11728947 Target ID T0985
Uniprot ID p38 mitogen-activated protein kinases Name p38 mitogen-activated protein kinases
Model vitro,rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Related Link

PubChem: 135484078
ChEMBL: