Mitogen-activated protein kinase 14

Basic Information

Uniprot ID: Q16539
Secondary ID: A6ZJ92
Symbol: MAPK14
Other Name: CSBP,MAP kinase 14,MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSAID-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Kinase,Serine/threonine-protein kinase,Transferase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0350 FR167653 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 23271722 Compound ID
CAS Name
Model human,mice Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,HSCs activation,cell apoptosis
Process III
Mechanism

Reference Record 2

PubMed ID 22166971 Compound ID D0350
CAS 158876-66-5 Name FR167653
Model rat Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 19526623 Compound ID D0350
CAS 158876-66-5 Name FR167653
Model pig Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 18515792 Compound ID D0350
CAS 158876-66-5 Name FR167653
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II myofibroblasts accumulation
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 16816533 Compound ID D0350
CAS 158876-66-5 Name FR167653
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism