Mitogen-activated protein kinase kinase kinase 5

Basic Information

Uniprot ID: Q99683
Secondary ID: A6NIA0
Symbol: MAP3K5
Other Name: ASK1,Apoptosis signal-regulating kinase 1,ASK-1,MAPKERK kinase kinase 5,MEK kinase 5,MEKK 5
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Kinase,Serine/threonine-protein kinase,Transferase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0194 GS-444217 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 26797817 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Glial scar
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 26180085 Compound ID D0194
CAS 1262041-49-5 Name GS-444217
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting ASK1-dependent p38 signaling

Reference Record 3

PubMed ID 25298527 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II cells proliferation,cells migration
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 17662399 Compound ID
CAS Name
Model hamster Fibrosis Disease Cardiac fibrosis
Process I
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 14551246 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism