Integrin-linked protein kinase

Basic Information

Uniprot ID: Q13418
Secondary ID: B7Z1I0
Symbol: ILK
Other Name: ILK1,59 kDa serinethreonine-protein kinase,ILK-1,ILK-2,p59ILK
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Kinase,Serine/threonine-protein kinase,Transferase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0051 CPD22 inhibitor
D0343 QLT0267 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28522687 Compound ID D0051
CAS 1333146-24-9 Name CPD22
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism Targeting ILK-Akt-mTOR pathway

Reference Record 2

PubMed ID 24756461 Compound ID
CAS Name
Model vitro Fibrosis Disease Peritoneal fibrosis
Process I
Process II EMT
Process III
Mechanism Targeting GSK-3β

Reference Record 3

PubMed ID 24383472 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III
Mechanism Targeting NF-κB pathway

Reference Record 4

PubMed ID 22310280 Compound ID D0343
CAS 866409-68-9 Name QLT0267
Model vitro Fibrosis Disease Fibrosis
Process I
Process II EMT,cells migration
Process III
Mechanism Targeting Snail and Slug

Reference Record 5

PubMed ID 20857141 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II EMT
Process III
Mechanism

Reference Record 6

PubMed ID 17656471 Compound ID D0343
CAS 866409-68-9 Name QLT0267
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II EMT
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 16941698 Compound ID
CAS Name
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation,HSCs apoptosis
Process III
Mechanism Targeting FAK, PI3K, ILK and the AKT/PKB pathway