Poly [ADP-ribose] polymerase tankyrase-1

Basic Information


Uniprot ID: O95271
Secondary ID: O95272, Q4G0F2
Symbol: TNKS
Other Name: PARP5A,ADP-ribosyltransferase diphtheria toxin-like 5,ARTD5,Poly [ADP-ribose] polymerase 5A,Protein poly-ADP-ribosyltransferase tankyrase-1,TNKS-1,TRF1-interacting ankyrin-related ADP-ribose polymerase,Tankyrase I,Tankyrase-1,TANK1
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Glycosyltransferase,Transferase


Target Classification


Category I Category II Category III
Intracellular Enzyme Transferase

Related Compound


Target ID Name Interaction
D0322 XAV-939 inhibitor

Fibrosis Related Property


Reference Record 1

PubMed ID 23148305 Compound ID D0322
CAS 284028-89-3 Name XAV-939
Model mice Fibrosis Disease Dermal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting Wnt signaling