3-hydroxy-3-methylglutaryl-coenzyme A reductase

Basic Information

Uniprot ID:	P04035
Secondary ID:	B7Z3Y9, Q8N190
Symbol:	HMGCR
Other Name:
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	Oxidoreductase

Target Classification

Category I	Category II	Category III
Intracellular	Enzyme	Oxidoreductase

Related Compound

Target ID	Name	Interaction
D0227	Lovastatin	inhibitor
D0558	Simvastatin	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	25646300	Compound ID	D0227
CAS	75330-75-5	Name	Lovastatin
Model	mice	Fibrosis Disease	Cardiac fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID	22525429	Compound ID	D0558
CAS	79902-63-9	Name	Simvastatin
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting HOXA13–USAG-1 pathway