Corticosteroid 11-beta-dehydrogenase isozyme 1

Basic Information


Uniprot ID: P28845
Secondary ID: B2R9Z1, D3DT89
Symbol: HSD11B1
Other Name: HSD11,11-beta-hydroxysteroid dehydrogenase 1,11-DH,11-beta-HSD1,Short chain dehydrogenasereductase family 26C member 1
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Oxidoreductase


Target Classification


Category I Category II Category III
Intracellular Enzyme Oxidoreductase

Related Compound


Target ID Name Interaction
D0520 PF915275 inhibitor

Fibrosis Related Property


Reference Record 1

PubMed ID 29221204 Compound ID D0520
CAS 857290-04-1 Name PF915275
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting EGFR