Bile acid receptor

Basic Information

Uniprot ID: Q96RI1
Secondary ID: A1L4K5
Symbol: NR1H4
Other Name: BAR,Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14
Class: Single Protein
Type: anti-fibrotic
Molecular Function: Activator,DNA-binding,Receptor,Repressor

Target Classification

Category I Category II Category III
Intracellular Nuclear receptor NR1 family

Related Compound

Target ID Name Interaction
D0103 GW4064 agonist
D0104 Chenodiol agonist
D0489 Obeticholic Acid agonist

Fibrosis Related Property

Reference Record 1

PubMed ID 27853248 Compound ID D0104
CAS 474-25-9 Name Chenodiol
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting FXR/Smad3 pathway

Reference Record 2

PubMed ID 27896916 Compound ID
CAS Name
Model human,mice,rat Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting FXR signaling

Reference Record 3

PubMed ID 27853248 Compound ID D0103
CAS 278779-30-9 Name GW4064
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting FXR/Smad3 pathway

Reference Record 4

PubMed ID 22265968 Compound ID
CAS Name
Model human Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism Targeting miR-199a-3p

Reference Record 5

PubMed ID 26655953 Compound ID D0489
CAS 459789-99-2 Name Obeticholic Acid
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism