Estrogen receptor

Basic Information

Uniprot ID: P03372
Secondary ID: Q13511
Symbol: ESR1
Other Name: ESR,ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
Class: Single Protein
Type: anti-fibrotic
Molecular Function: Activator,DNA-binding,Receptor

Target Classification

Category I Category II Category III
Intracellular Nuclear receptor NR3 family

Related Compound

Target ID Name Interaction
D0389 17β-Estradiol (E2) agonist
D0490 Fulvestrant inhibitor
D1127 Dipropylnitrile agonist

Fibrosis Related Property

Reference Record 1

PubMed ID 20810711 Compound ID D0389
CAS 50-28-2 Name 17β-Estradiol (E2)
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 20810711 Compound ID D1127
CAS Name Dipropylnitrile
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 27025157 Compound ID D0490
CAS 129453-61-8 Name Fulvestrant
Model vitro,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism Targeting ERK1/2