Nuclear factor erythroid 2-related factor 2

Basic Information

Uniprot ID: Q16236
Secondary ID: B2RBU2
Symbol: NFE2L2
Other Name: NRF2,NF-E2-related factor 2,NFE2-related factor 2,HEBP1,Nuclear factor, erythroid derived 2, like 2
Class: Single Protein
Type: pro/anti-fibrotic
Molecular Function: Activator,DNA-binding

Target Classification

Category I Category II Category III
Intracellular Nuclear receptor

Related Compound

Target ID Name Interaction
D0020 Chrysophanol activator
D0211 RTA dh404 activator
D0493 Sulforaphane activator

Fibrosis Related Property

Reference Record 1

PubMed ID 28821730 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III
Mechanism

Reference Record 2

PubMed ID 28738526 Compound ID D0020
CAS 481-74-3 Name Chrysophanol
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III
Mechanism

Reference Record 3

PubMed ID 28601022 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation
Process III prevenet collagen deposition
Mechanism Targeting JAK2/STAT3 signaling

Reference Record 4

PubMed ID 26494449 Compound ID D0493
CAS 4478-93-7 Name Sulforaphane
Model mice Fibrosis Disease Muscle fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGF-β/Smad signaling

Reference Record 5

PubMed ID 25930007 Compound ID D0211
CAS 1191265-33-4 Name RTA dh404
Model rat Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 23028668 Compound ID D0211
CAS 1191265-33-4 Name RTA dh404
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 23023374 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II cells migration,cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 22703534 Compound ID D0493
CAS 4478-93-7 Name Sulforaphane
Model vitro,human,mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II fibroblasts proliferation,fibroblasts differentiation,fibroblasts migration
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 21712086 Compound ID
CAS Name
Model mice Fibrosis Disease Pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 19926817 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 18679376 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 12

PubMed ID 28457937 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism