Mothers against decapentaplegic homolog 3

Basic Information

Uniprot ID: P84022
Secondary ID: A8K4B6
Symbol: SMAD3
Other Name: MADH3,MAD homolog 3,Mad3,Mothers against DPP homolog 3,hMAD-3,JV15-2,SMAD family member 3,SMAD 3,Smad3,hSMAD3
Class: Single Protein
Type: pro-fibrotic
Molecular Function: DNA-binding

Target Classification

Category I Category II Category III
Intracellular Other transcription factor Transcription activator

Related Compound

Target ID Name Interaction
D0190 SIS3 inhibitor
D0471 Naringenin inhibitor
D1163 Proteolysis targeting chimeric molecules for SMAD3 other

Fibrosis Related Property

Reference Record 1

PubMed ID 27473774 Compound ID D1163
CAS Name Proteolysis targeting chimeric molecules for SMAD3
Model Fibrosis Disease Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 2

PubMed ID 26221756 Compound ID D0190
CAS 521984-48-5 Name SIS3
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 25945408 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 25351340 Compound ID
CAS Name
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 24744860 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 24737245 Compound ID
CAS Name
Model vitro,rabbit Fibrosis Disease Vocal fold fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 19966781 Compound ID D0190
CAS 521984-48-5 Name SIS3
Model vitro,mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 19956083 Compound ID
CAS Name
Model mice Fibrosis Disease Peritoneal fibrosis
Process I
Process II EMT
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 19422482 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 19200168 Compound ID
CAS Name
Model mice Fibrosis Disease Intestinal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 17967775 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 12

PubMed ID 16341574 Compound ID D0471
CAS 480-41-1 Name Naringenin
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation
Process III prevenet collagen deposition
Mechanism Targeting TGF-β1-Smad3 signaling

Reference Record 13

PubMed ID 16298342 Compound ID
CAS Name
Model vitro Fibrosis Disease Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 14

PubMed ID 11839555 Compound ID
CAS Name
Model mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 15

PubMed ID 11839555 Compound ID
CAS Name
Model mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism