Hypoxia-inducible factor 1-alpha

Basic Information

Uniprot ID: Q16665
Secondary ID: C0LZJ3
Symbol: HIF1A
Other Name: BHLHE78,HIF-1-alpha,HIF1-alpha,ARNT-interacting protein,Basic-helix-loop-helix-PAS protein MOP1,Class E basic helix-loop-helix protein 78,bHLHe78,Member of PAS protein 1,PAS domain-containing protein 8
Class: Single Protein
Type: pro/anti-fibrotic
Molecular Function: Activator,DNA-binding

Target Classification

Category I Category II Category III
Intracellular Other transcription factor Transcription activator

Related Compound

Target ID Name Interaction
D0155 Lificiguat inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28439208 Compound ID
CAS Name
Model human Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting HBx

Reference Record 2

PubMed ID 27271610 Compound ID
CAS Name
Model vitro Fibrosis Disease Pancreatic fibrosis
Process I
Process II
Process III
Mechanism Targeting CCR2/CCR4

Reference Record 3

PubMed ID 26908870 Compound ID D0155
CAS 170632-47-0 Name Lificiguat
Model mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting NOX4

Reference Record 4

PubMed ID 26781174 Compound ID
CAS Name
Model vitro,rat Fibrosis Disease Pulmonary fibrosis
Process I
Process II EMT
Process III
Mechanism Targeting Snail and β-catenin pathways

Reference Record 5

PubMed ID 26637636 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 23466866 Compound ID
CAS Name
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II EMT
Process III
Mechanism

Reference Record 7

PubMed ID 21777345 Compound ID
CAS Name
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 19546236 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Tissue fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 9

PubMed ID 18667485 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 17761615 Compound ID
CAS Name
Model human,mice Fibrosis Disease Pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 16289155 Compound ID
CAS Name
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III
Mechanism

Reference Record 12

PubMed ID 14708599 Compound ID
CAS Name
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III
Mechanism

Reference Record 13

PubMed ID 28106131 Compound ID
CAS Name
Model vitro,rat Fibrosis Disease Renal fibrosis
Process I
Process II EMT
Process III prevenet collagen deposition
Mechanism