Zinc finger protein GLI2

Basic Information

Uniprot ID: P10070
Secondary ID: O60252
Symbol: GLI2
Other Name: THP,GLI family zinc finger protein 2,Tax helper protein
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Activator,Developmental protein,DNA-binding,Repressor

Target Classification

Category I Category II Category III
Intracellular Other transcription factor Both activator and repressor

Related Compound

Target ID Name Interaction
D0106 GANT61 inhibitor
D0192 Darinaparsin binder

Fibrosis Related Property

Reference Record 1

PubMed ID 27793816 Compound ID D0106
CAS 500579-04-4 Name GANT61
Model vitro,human,mice Fibrosis Disease Systemic sclerosis
Process I
Process II fibroblasts activation
Process III prevenet collagen deposition
Mechanism Targeting TGF-β signaling

Reference Record 2

PubMed ID 26823780 Compound ID
CAS Name
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 26193634 Compound ID D0106
CAS 500579-04-4 Name GANT61
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 26193634 Compound ID D0192
CAS 69819-86-9 Name Darinaparsin
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism