Cellular tumor antigen p53

Basic Information

Uniprot ID: P04637
Secondary ID: Q15086
Symbol: TP53
Other Name: P53,Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53
Class: Single Protein
Type: pro/anti-fibrotic
Molecular Function: Activator,DNA-binding,Repressor

Target Classification

Category I Category II Category III
Intracellular Other transcription factor Both activator and repressor

Related Compound

Target ID Name Interaction
D0522 RG7112 agonist
D0545 Pifithrin-α inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28240316 Compound ID D0545
CAS 63208-82-2 Name Pifithrin-α
Model vitro,human,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting STAT3

Reference Record 2

PubMed ID 25713289 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 24854277 Compound ID
CAS Name
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 24040275 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 23650131 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 6

PubMed ID 23035104 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Scar
Process I
Process II cells proliferation
Process III
Mechanism

Reference Record 7

PubMed ID 21747166 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 21146511 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 29211796 Compound ID D0522
CAS 939981-39-2 Name RG7112
Model vitro,mice Fibrosis Disease Pancreatic fibrosis
Process I
Process II cells activation,cells proliferation,cell migration
Process III prevenet collagen deposition
Mechanism