Sterol regulatory element-binding protein 2

Basic Information


Uniprot ID: Q12772
Secondary ID: Q05BD5
Symbol: SREBF2
Other Name: BHLHD2,SREBP-2,Class D basic helix-loop-helix protein 2,bHLHd2,Sterol regulatory element-binding transcription factor 2,Processed sterol regulatory element-binding protein 2
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Activator,DNA-binding


Target Classification


Category I Category II Category III
Intracellular Other transcription factor Both activator and repressor

Related Compound


Target ID Name Interaction
D0552 Fatostatin inhibitor

Fibrosis Related Property


Reference Record 1

PubMed ID 27385736 Compound ID D0552
CAS 298197-04-3 Name Fatostatin
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II fibroblasts activation
Process III prevenet collagen deposition
Mechanism